A 4-sphere with non central radius and its instanton sheaf

We build an SU(2)-Hopf bundle over a quantum toric four-sphere whose radius is non central. The construction is carried out using local methods in terms of sheaves of Hopf-Galois extensions. The associated instanton bundle is presented and endowed with a connection with anti-selfdual curvature.Comment: minor changes, appendix section extended. To appear in Letters in Mathematical Physics. 22 pages, no figure

The quantum Cartan algebra associated to a bicovariant differential calculus

We associate to any (suitable) bicovariant differential calculus on a quantum group a Cartan Hopf algebra which has a left, respectively right, representation in terms of left, respectively right, Cartan calculus operators. The example of the Hopf algebra associated to the $4D_+$ differential calculus on $SU_q(2)$ is described.Comment: 20 pages, no figures. Minor corrections in the example in Section 4

Increasing entanglement through engineered disorder in the random Ising chain

The ground state entanglement entropy between block of sites in the random Ising chain is studied by means of the Von Neumann entropy. We show that in presence of strong correlations between the disordered couplings and local magnetic fields the entanglement increases and becomes larger than in the ordered case. The different behavior with respect to the uncorrelated disordered model is due to the drastic change of the ground state properties. The same result holds also for the random 3-state quantum Potts model.Comment: 4 pages, published version, a few typos correcte

Segmented Strings in AdS3AdS_3

We study segmented strings in flat space and in $AdS_3$. In flat space, these well known classical motions describe strings which at any instant of time are piecewise linear. In $AdS_3$, the worldsheet is composed of faces each of which is a region bounded by null geodesics in an $AdS_2$ subspace of $AdS_3$. The time evolution can be described by specifying the null geodesic motion of kinks in the string at which two segments are joined. The outcome of collisions of kinks on the worldsheet can be worked out essentially using considerations of causality. We study several examples of closed segmented strings in $AdS_3$ and find an unexpected quasi-periodic behavior. We also work out a WKB analysis of quantum states of yo-yo strings in $AdS_3$ and find a logarithmic term reminiscent of the logarithmic twist of string states on the leading Regge trajectory.Comment: 38 pages, 5 figure

Minimal Super Technicolor

We introduce novel extensions of the Standard Model featuring a supersymmetric technicolor sector. First we consider N=4 Super Yang-Mills which breaks to N=1 via the electroweak (EW) interactions and coupling to the MSSM. This is a well defined, economical and calculable extension of the SM involving the smallest number of fields. It constitutes an explicit example of a natural supersymmetric conformal extension of the Standard Model featuring a well defined connection to string theory. It allows to interpolate, depending on how we break the underlying supersymmetry, between unparticle physics and Minimal Walking Technicolor. As a second alternative we consider other N =1 extensions of the Minimal Walking Technicolor model. The new models allow all the standard model matter fields to acquire a mass.Comment: Improved version demonstrating that this extension is phenomenologically viable. No Landau pole exists in the theory to two loops level. This is the first theory showing that supersymmetry can solve the flavor problem when coupled to low energy technicolo

Density Matrix Renormalization Group for Dummies

We describe the Density Matrix Renormalization Group algorithms for time dependent and time independent Hamiltonians. This paper is a brief but comprehensive introduction to the subject for anyone willing to enter in the field or write the program source code from scratch.Comment: 29 pages, 9 figures. Published version. An open source version of the code can be found at http://qti.sns.it/dmrg/phome.htm

Development and Role in Therapy of Canakinumab in Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other pro-inflammatory cytokines gives rise to the development of new targeted therapies. Currently, AOSD patients can benefit from efficient and well tolerated biologic agents, such as IL-1, IL-6, and tumour necrosis factor (TNF)-\u3b1 antagonists. Canakinumab, a human monoclonal anti-IL-1\u3b2 antibody, is indicated for the treatment of different autoinflammatory syndromes in adults, adolescents, and children and it has recently been approved for AOSD treatment. In this article, we summarize the structural and biochemical data describing the molecular interactions between Canakinumab and its target antigen. Some special considerations of the pharmacological properties of Canakinumab are included. We also review the safety, efficacy and tolerability of this drug for the treatment of AOSD

Entanglement properties of spin models in triangular lattices

The different quantum phases appearing in strongly correlated systems as well as their transitions are closely related to the entanglement shared between their constituents. In 1D systems, it is well established that the entanglement spectrum is linked to the symmetries that protect the different quantum phases. This relation extends even further at the phase transitions where a direct link associates the entanglement spectrum to the conformal field theory describing the former. For 2D systems much less is known. The lattice geometry becomes a crucial aspect to consider when studying entanglement and phase transitions. Here, we analyze the entanglement properties of triangular spin lattice models by considering also concepts borrowed from quantum information theory such as geometric entanglement.Comment: 19 pages, 8 figure